Food
Isoflavone-containing foods can support lipid and menopausal-symptom endpoints in subsets.[2977,3166,3167, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
96/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Classification: case-dependent.[1132,1283,2977, etc.]
Best fit: Users replacing processed meat with plant protein..[1132,1283,2977, etc.]
Goal alignment: Heart Health, Hormone Health, Bone Health.[1132,1283,2977, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users replacing processed meat with plant protein.
Primary Focus
Heart Health, Hormone Health
Clinical Depth
Humans: 3,338 • RCTs: 623 • Meta: 154
Cohort / Real-World
Cohort signals: 407
Safety Markers
Adverse signals: 137 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
3338 total studies · 2 recent
Timeline
Total indexed
3,338
Human studies
3,338
Randomized trials
623
In vitro / tissue
573
Cohort signals
407
Meta-analyses
154
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
3,338
Human studies
3,338
Randomized trials
623
In vitro / tissue
573
Cohort signals
407
Meta-analyses
154
Safety adverse signals
137
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33383165 • 2021 Mar
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies.
Reprod Toxicol
Open PubMedPMID 35241506 • 2022 Mar-Apr
Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.
In Vivo
Open PubMedPMID 34348965 • 2021 Aug 4
Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials.
BMJ
Open PubMedPMID 30485934 • 2018
Dietary factors and risk of gout and hyperuricemia: a meta-analysis and systematic review.
Asia Pac J Clin Nutr
Open PubMedPMID 40533200 • 2025 Jun 18
Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials.
BMJ
Open PubMedPMID 33762150 • 2021 May 6
The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 29562612 • 2018 Mar 17
Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial.
Nutrients
Open PubMedPMID 34358827 • 2021 Aug
Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial.
Clin Nutr
Open PubMedPMID 39275135 • 2024 Aug 23
The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials.
Nutrients
Open PubMedPMID 33726784 • 2021 Mar 16
Effect of whey vs. soy protein supplementation on recovery kinetics following speed endurance training in competitive male soccer players: a randomized controlled trial.
J Int Soc Sports Nutr
Open PubMedPMID 35105389 • 2022 Oct 28
The plasma amino acid response to blended protein beverages: a randomised crossover trial.
Br J Nutr
Open PubMedPMID 30485922 • 2018
Acute effect of soy and soy products on serum uric acid concentration among healthy Chinese men.
Asia Pac J Clin Nutr
Open PubMedPMID 32095830 • 2020 Oct 1
Dairy, soy, and risk of breast cancer: those confounded milks.
Int J Epidemiol
Open PubMedPMID 30742825 • 2019 Jun
Dietary patterns and outcomes of assisted reproduction.
Am J Obstet Gynecol
Open PubMedPMID 37877288 • 2023 Nov 28
Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies.
Circulation
Open PubMedPMID 36162007 • 2023 Jan 1
The Portfolio Diet and Incident Type 2 Diabetes: Findings From the Women's Health Initiative Prospective Cohort Study.
Diabetes Care
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22soy%20foods%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=soy%20foods
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 3338, RCT 623, meta 154, cohort 407.[2977,3166,3167, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33383165 from Reprod Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35241506 from In Vivo.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34348965 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30485934 from Asia Pac J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40533200 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33762150 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29562612 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34358827 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39275135 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33726784 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35105389 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30485922 from Asia Pac J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32095830 from Int J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30742825 from Am J Obstet Gynecol.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37877288 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36162007 from Diabetes Care.
Outcome: See linked PubMed abstract for methods and outcomes.[2977,3166,3167, etc.]
Open source