Food
Any potential polyphenol signal is counterbalanced by alcohol exposure risk.[1459,1612,1871, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
76/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: case-dependent.[1120,1266,1459, etc.]
Best fit: Users who already consume alcohol and are reducing harm..[1120,1266,1459, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users who already consume alcohol and are reducing harm.
Primary Focus
Heart Health, Mood
Clinical Depth
Humans: 1,217 • RCTs: 159 • Meta: 15
Cohort / Real-World
Cohort signals: 155
Safety Markers
Adverse signals: 48 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1217 total studies · 7 recent
Timeline
Total indexed
1,217
Human studies
1,217
In vitro / tissue
378
Randomized trials
159
Cohort signals
155
Safety adverse signals
48
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
1,217
Human studies
1,217
In vitro / tissue
378
Randomized trials
159
Cohort signals
155
Safety adverse signals
48
Meta-analyses
15
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 30864165 • 2019 Mar 13
Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease.
Cochrane Database Syst Rev
Open PubMedPMID 39557282 • 2025 Feb
White diet is not necessary during dental bleaching treatment: A systematic review and network meta-analysis of clinical studies.
J Dent
Open PubMedPMID 39940392 • 2025 Jan 31
Consumption of Red Versus White Wine and Cancer Risk: A Meta-Analysis of Observational Studies.
Nutrients
Open PubMedPMID 39950360 • 2025 Jan 19
Association between wine consumption and migraine: a systematic review and meta-analysis of cross-sectional.
Alcohol Alcohol
Open PubMedPMID 40121963 • 2025 Jun
The effects of wine consumption and lipid profile: A systematic review and meta-analysis of clinical trials.
J Nutr Health Aging
Open PubMedPMID 38847707 • 2024 Jun 7
Red wine alleviates atherosclerosis-related inflammatory markers in healthy subjects rather than in high cardiovascular risk subjects: A systematic review and meta-analysis.
Medicine (Baltimore)
Open PubMedPMID 36513442 • 2022 Dec
Evaluation of cardiovascular risk biomarkers after moderate consumption of red wine and cachaça in a randomized crossover trial: The Wine and Cachaça Study (WICAS).
Clin Nutr ESPEN
Open PubMedPMID 27692023 • 2017 Feb
Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial.
Public Health Nutr
Open PubMedPMID 35986934 • 2022 Aug
Influence of diet and red wine exposure on the velocity of at home bleaching: A randomized controlled clinical trial.
Am J Dent
Open PubMedPMID 26232779 • 2016 Apr
Differential Effect of Initiating Moderate Red Wine Consumption on 24-h Blood Pressure by Alcohol Dehydrogenase Genotypes: Randomized Trial in Type 2 Diabetes.
Am J Hypertens
Open PubMedPMID 36205549 • 2022 Dec 19
A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition.
Am J Clin Nutr
Open PubMedPMID 11719733 • 2001 Nov
Red wine decreases cyclosporine bioavailability.
Clin Pharmacol Ther
Open PubMedPMID 38336153 • 2024 Jul
Effect of the Mediterranean diet in cardiovascular prevention.
Rev Esp Cardiol (Engl Ed)
Open PubMedPMID 39292460 • 2024 Sep 3
Flavonoid-Rich Foods, Dementia Risk, and Interactions With Genetic Risk, Hypertension, and Depression.
JAMA Netw Open
Open PubMedPMID 18942526 • 2006 Dec
Red wine and cardiovascular risks.
Arch Mal Coeur Vaiss
Open PubMedPMID 15482625 • 2004 Oct
Mediterranean diet and cognitive decline.
Public Health Nutr
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22red%20wine%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=red%20wine
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 1217, RCT 159, meta 15, cohort 155.[1459,1612,1871, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30864165 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39557282 from J Dent.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39940392 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39950360 from Alcohol Alcohol.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40121963 from J Nutr Health Aging.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38847707 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36513442 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27692023 from Public Health Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35986934 from Am J Dent.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26232779 from Am J Hypertens.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36205549 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11719733 from Clin Pharmacol Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38336153 from Rev Esp Cardiol (Engl Ed).
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39292460 from JAMA Netw Open.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 18942526 from Arch Mal Coeur Vaiss.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open sourcePUBMED • 2004 • Human evidence curation set
PMID 15482625 from Public Health Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1459,1612,1871, etc.]
Open source