Food
Highly absorbable inorganic phosphate additives can increase phosphorus burden.[2092,2331,3186, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
41/100
Early depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
35/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 0 • links 18
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Classification: limit.[1114,1255,2092, etc.]
Best fit: Users with kidney disease risk and high processed-food intake..[1114,1255,2092, etc.]
Goal alignment: Bone Health, Heart Health, Metabolic Health.[1114,1255,2092, etc.]
Classification
Limit
Evidence Tier
MEDIUM
Best Fit
Users with kidney disease risk and high processed-food intake.
Primary Focus
Bone Health, Heart Health
Clinical Depth
Humans: 29 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 3
Safety Markers
Adverse signals: 5 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
29 total studies
Timeline
Total indexed
29
Human studies
29
Safety adverse signals
5
Cohort signals
3
Animal-only studies
0
In vitro / tissue
0
Weighted direction score: 0 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when non-human evidence volume is substantial.
Total indexed
29
Human studies
29
Safety adverse signals
5
Cohort signals
3
Animal-only studies
0
In vitro / tissue
0
Randomized trials
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 22334826 • 2012 Jan
Phosphate additives in food--a health risk.
Dtsch Arztebl Int
Open PubMedPMID 24984987 • 2014 Jul-Aug
Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives.
Nutrition
Open PubMedPMID 32466982 • 2021 Mar
Dietary Phosphate Consumption in Australians With Stages 3b and 4 Chronic Kidney Disease.
J Ren Nutr
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 29, RCT 0, meta 0, cohort 3.[2092,2331,3186, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22334826 from Dtsch Arztebl Int.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
PMID 35010952 • 2021 Dec 24
Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid.
Nutrients
Open PubMedPMID 37630701 • 2023 Aug 9
Industrial Use of Phosphate Food Additives: A Mechanism Linking Ultra-Processed Food Intake to Cardiorenal Disease Risk?
Nutrients
Open PubMedPMID 37309057 • 2023 Jun 13
Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research.
Expert Rev Mol Med
Open PubMedPMID 35288876 • 2022
Common Dietary Sources of Natural and Artificial Phosphate in Food.
Adv Exp Med Biol
Open PubMedPMID 30686528 • 2019 Apr
Dietary Phosphate and the Forgotten Kidney Patient: A Critical Need for FDA Regulatory Action.
Am J Kidney Dis
Open PubMedPMID 30587596 • 2019 Jan-Feb
Lack of Awareness of Dietary Sources of Phosphorus Is a Clinical Concern.
In Vivo
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=phosphate%20additives
Community Sources
PUBMED • 2014 • Human evidence curation set
PMID 24984987 from Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32466982 from J Ren Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 35010952 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37630701 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37309057 from Expert Rev Mol Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35288876 from Adv Exp Med Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30686528 from Am J Kidney Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30587596 from In Vivo.
Outcome: See linked PubMed abstract for methods and outcomes.[2092,2331,3186, etc.]
Open source