Food
Manufactured trans-fat source strongly associated with adverse cardiometabolic outcomes.[1449,1512,1693, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
58/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: limit.[1113,1253,1449, etc.]
Best fit: All users..[1113,1253,1449, etc.]
Goal alignment: Heart Health, Longevity.[1113,1253,1449, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
All users.
Primary Focus
Heart Health, Longevity
Clinical Depth
Humans: 172 • RCTs: 32 • Meta: 4
Cohort / Real-World
Cohort signals: 17
Safety Markers
Adverse signals: 18 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
172 total studies
Timeline
Total indexed
172
Human studies
172
Randomized trials
32
Safety adverse signals
18
Cohort signals
17
Meta-analyses
4
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
172
Human studies
172
Randomized trials
32
Safety adverse signals
18
Cohort signals
17
Meta-analyses
4
In vitro / tissue
2
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 34104953 • 2021 Jun 4
Dietary trans-fatty acid intake in relation to cancer risk: a systematic review and meta-analysis.
Nutr Rev
Open PubMedPMID 25995283 • 2015 Jul
Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials.
J Nutr
Open PubMedPMID 19424216 • 2009 May
Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils.
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22partially%20hydrogenated%20oils%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 172, RCT 32, meta 4, cohort 17.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34104953 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
Eur J Clin Nutr
PMID 11592728 • 2001 Aug
Serum cholesterol predictive equations with special emphasis on trans and saturated fatty acids. an analysis from designed controlled studies.
Lipids
Open PubMedPMID 30773586 • 2019 Mar 1
Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity.
J Nutr
Open PubMedPMID 33596340 • 2021 May
Consumption of High-Oleic Soybean Oil Improves Lipid and Lipoprotein Profile in Humans Compared to a Palm Oil Blend: A Randomized Controlled Trial.
Lipids
Open PubMedPMID 26561632 • 2015 Dec
Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 20437207 • 2010 May
Effects of partially hydrogenated, semi-saturated, and high oleate vegetable oils on inflammatory markers and lipids.
Lipids
Open PubMedPMID 16825681 • 2006 Jul
Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects.
Am J Clin Nutr
Open PubMedPMID 12540404 • 2003 Feb
Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren.
Am J Clin Nutr
Open PubMedPMID 22583051 • 2012 Jul
Dietary fats and coronary heart disease.
J Intern Med
Open PubMedPMID 36542554 • 2023 Feb 1
Different Types of Industry-Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes: Findings From the NutriNet-Santé Prospective Cohort.
Diabetes Care
Open PubMedPMID 19916363 • 2009 Sep-Oct
Consumption and health effects of trans fatty acids: a review.
J AOAC Int
Open PubMedPMID 18996687 • 2008 Sep-Nov
Trans fatty acids: effects on cardiometabolic health and implications for policy.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 34724806 • 2021 Dec 7
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association.
Circulation
Open PubMedPMID 32738189 • 2020 Aug
Evolution of Trans-fatty acid consumption in Thailand and strategies for its reduction.
J Clin Hypertens (Greenwich)
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=partially%20hydrogenated%20oils
Community Sources
PUBMED • 2015 • Human evidence curation set
PMID 25995283 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19424216 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11592728 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30773586 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33596340 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26561632 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20437207 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16825681 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 12540404 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22583051 from J Intern Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36542554 from Diabetes Care.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19916363 from J AOAC Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18996687 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34724806 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32738189 from J Clin Hypertens (Greenwich).
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open source