Food
Most users tolerate nightshades well; a subset report symptom changes in elimination-rechallenge trials.[2962,3384,4842, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
37/100
Early depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
21/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 5 • mentions 0 • links 14
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Classification: case-dependent.[1110,1248,2962, etc.]
Best fit: Users conducting structured symptom tracking for autoimmune-style complaints..[1110,1248,2962, etc.]
Goal alignment: Joint Health, Gut Health.[1110,1248,2962, etc.]
Classification
Case Dependent
Evidence Tier
LOW
Best Fit
Users conducting structured symptom tracking for autoimmune-style complaints.
Primary Focus
Joint Health, Gut Health
Clinical Depth
Humans: 7 • RCTs: 0 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 2 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
7 total studies · 2 recent
Timeline
Total indexed
7
Human studies
7
Safety adverse signals
2
Meta-analyses
1
Animal-only studies
0
In vitro / tissue
0
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Low when evidence remains sparse and mostly preclinical/in vitro.
Total indexed
7
Human studies
7
Safety adverse signals
2
Meta-analyses
1
Animal-only studies
0
In vitro / tissue
0
Randomized trials
0
Cohort signals
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 29518971 • 2018 Mar 7
Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.
Int J Mol Sci
Open PubMedPMID 37202602 • 2023 Jul
Nightshade Vegetables: A Dietary Trigger for Worsening Inflammatory Bowel Disease and Irritable Bowel Syndrome?
Dig Dis Sci
Open PubMedPMID 39768986 • 2024 Dec 23
The Impact of Diet on Hidradenitis Suppurativa Severity: A Cross-Sectional Case-Control Study.
Medicina (Kaunas)
Open PubMedPMID 39127701 • 2024 Aug 10
The evaluation of nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients: study protocol for a randomized controlled trial.
Trials
Open PubMedPMID 31456135 • 2020 Jan
Atropa belladonna Expresses a microRNA (aba-miRNA-9497) Highly Homologous to Homo sapiens miRNA-378 (hsa-miRNA-378); both miRNAs target the 3'-Untranslated Region (3'-UTR) of the mRNA Encoding the Neurologically Relevant, Zinc-Finger Transcription Factor ZNF-691.
Cell Mol Neurobiol
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=nightshade%20vegetables
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 7, RCT 0, meta 1, cohort 0.[2962,3384,4842, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29518971 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2962,3384,4842, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37202602 from Dig Dis Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2962,3384,4842, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39768986 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[2962,3384,4842, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39127701 from Trials.
Outcome: See linked PubMed abstract for methods and outcomes.[2962,3384,4842, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31456135 from Cell Mol Neurobiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2962,3384,4842, etc.]
Open source