Food
Partially hydrogenated fats worsen lipoprotein profiles and inflammatory markers.[1449,1876,1945, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
65/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: limit.[1099,1225,1449, etc.]
Best fit: All users..[1099,1225,1449, etc.]
Goal alignment: Heart Health, Longevity, Metabolic Health.[1099,1225,1449, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
All users.
Primary Focus
Heart Health, Longevity
Clinical Depth
Humans: 406 • RCTs: 29 • Meta: 5
Cohort / Real-World
Cohort signals: 59
Safety Markers
Adverse signals: 27 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
406 total studies
Timeline
Total indexed
406
Human studies
406
Cohort signals
59
Randomized trials
29
Safety adverse signals
27
In vitro / tissue
15
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
406
Human studies
406
Cohort signals
59
Randomized trials
29
Safety adverse signals
27
In vitro / tissue
15
Meta-analyses
5
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33762150 • 2021 May 6
The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 26268692 • 2015 Aug 11
Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies.
BMJ
Open PubMedPMID 30573335 • 2019 Feb
A Meta-Analysis of Food Labeling Effects on Consumer Diet Behaviors and Industry Practices.
Am J Prev Med
Open PubMedPMID 21427742 • 2011 Jul
Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.
Eur J Clin Nutr
Open PubMedPMID 11592728 • 2001 Aug
Serum cholesterol predictive equations with special emphasis on trans and saturated fatty acids. an analysis from designed controlled studies.
Lipids
Open PubMedPMID 33445809 • 2021 Jan 12
Dietary Intake of trans Fatty Acids in the Slovenian Population.
Nutrients
Open PubMedPMID 27899529 • 2017 Mar
Short-term effects of trans fatty acids from ruminant and industrial sources on surrogate markers of cardiovascular risk in healthy men and women: A randomized, controlled, double-blind trial.
Eur J Prev Cardiol
Open PubMedPMID 25616935 • 2016 Feb
Nutritional adequacy according to carbohydrates and fat quality.
Eur J Nutr
Open PubMedPMID 26561632 • 2015 Dec
Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 23922748 • 2013
Effect of trans fatty acid intake on LC-MS and NMR plasma profiles.
PLoS One
Open PubMedPMID 21397284 • 2011 Jul
Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women.
Metabolism
Open PubMedPMID 30309780 • 2019 May
Trans-fatty Acids and Survival in Renal Transplantation.
J Ren Nutr
Open PubMedPMID 18996687 • 2008 Sep-Nov
Trans fatty acids: effects on cardiometabolic health and implications for policy.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 19916363 • 2009 Sep-Oct
Consumption and health effects of trans fatty acids: a review.
J AOAC Int
Open PubMedPMID 24636816 • 2014 Mar 1
Trans fatty acids: are its cardiovascular risks fully appreciated?
Clin Ther
Open PubMedPMID 31782488 • 2020 May 1
Mechanisms of Action of trans Fatty Acids.
Adv Nutr
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22industrial%20trans%20fats%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=industrial%20trans%20fats
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 406, RCT 29, meta 5, cohort 59.[1449,1876,1945, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33762150 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26268692 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30573335 from Am J Prev Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21427742 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11592728 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33445809 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27899529 from Eur J Prev Cardiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 25616935 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26561632 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23922748 from PLoS One.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21397284 from Metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30309780 from J Ren Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18996687 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19916363 from J AOAC Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24636816 from Clin Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31782488 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1876,1945, etc.]
Open source