Food
High added-fructose exposure from beverages/processed foods can worsen liver fat and glycemic outcomes.[1877,2249,2344, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
52/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: limit.[1095,1219,1877, etc.]
Best fit: Users with fatty liver risk and high sweetened beverage intake..[1095,1219,1877, etc.]
Goal alignment: Metabolic Health, Liver Support, Body Composition.[1095,1219,1877, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
Users with fatty liver risk and high sweetened beverage intake.
Primary Focus
Metabolic Health, Liver Support
Clinical Depth
Humans: 304 • RCTs: 28 • Meta: 12
Cohort / Real-World
Cohort signals: 25
Safety Markers
Adverse signals: 13 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
304 total studies
Timeline
Total indexed
304
Human studies
304
Randomized trials
28
Cohort signals
25
In vitro / tissue
15
Safety adverse signals
13
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
304
Human studies
304
Randomized trials
28
Cohort signals
25
In vitro / tissue
15
Safety adverse signals
13
Meta-analyses
12
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 38201905 • 2023 Dec 25
The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 25099546 • 2014 Sep
Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis.
Am J Clin Nutr
Open PubMedPMID 33029629 • 2021 Jan 9
Effect of fructose instead of glucose or sucrose on cardiometabolic markers: a systematic review and meta-analysis of isoenergetic intervention trials.
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 304, RCT 28, meta 12, cohort 25.[1877,2249,2344, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38201905 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
Nutr Rev
PMID 29757229 • 2018 May 12
Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies.
Nutrients
Open PubMedPMID 30463844 • 2018 Nov 21
Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.
BMJ
Open PubMedPMID 18996880 • 2008 Nov
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies.
Am J Clin Nutr
Open PubMedPMID 26537945 • 2015 Dec
No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial.
Am J Clin Nutr
Open PubMedPMID 29795005 • 2018 May 24
High-Fructose Corn-Syrup-Sweetened Beverage Intake Increases 5-Hour Breast Milk Fructose Concentrations in Lactating Women.
Nutrients
Open PubMedPMID 27357093 • 2016 Aug
No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 33904664 • 2021 Apr
Arterial stiffness is not acutely modified by consumption of a caffeinated soft drink sweetened with high-fructose corn syrup in young healthy adults.
Physiol Rep
Open PubMedPMID 26338891 • 2015 Oct
Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals.
J Nutr
Open PubMedPMID 24267044 • 2013 Dec
High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels.
Nutr Res
Open PubMedPMID 31521398 • 2019 Dec
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Rev Neurol (Paris)
Open PubMedPMID 29219619 • 2018 Feb
Prenatal and Early Life Fructose, Fructose-Containing Beverages, and Midchildhood Asthma.
Ann Am Thorac Soc
Open PubMedPMID 27001645 • 2016 Mar
Physiological handling of dietary fructose-containing sugars: implications for health.
Int J Obes (Lond)
Open PubMedPMID 30060614 • 2018 Jul 29
French Recommendations for Sugar Intake in Adults: A Novel Approach Chosen by ANSES.
Nutrients
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=high-fructose%20corn%20syrup
Community Sources
PUBMED • 2014 • Human evidence curation set
PMID 25099546 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33029629 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29757229 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30463844 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18996880 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26537945 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29795005 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27357093 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33904664 from Physiol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26338891 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 24267044 from Nutr Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31521398 from Rev Neurol (Paris).
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29219619 from Ann Am Thorac Soc.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27001645 from Int J Obes (Lond).
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30060614 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1877,2249,2344, etc.]
Open source