Food
Whole-grain gluten sources can be beneficial for many users but harmful in celiac disease.[2975,2977,3064, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: case-dependent.[1089,1212,2975, etc.]
Best fit: Users without celiac disease who tolerate whole grains..[1089,1212,2975, etc.]
Goal alignment: Gut Health, Metabolic Health.[1089,1212,2975, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users without celiac disease who tolerate whole grains.
Primary Focus
Gut Health, Metabolic Health
Clinical Depth
Humans: 7,617 • RCTs: 243 • Meta: 79
Cohort / Real-World
Cohort signals: 761
Safety Markers
Adverse signals: 188 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
7617 total studies · 6 recent
Timeline
Total indexed
7,617
Human studies
7,617
Cohort signals
761
In vitro / tissue
492
Randomized trials
243
Safety adverse signals
188
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
7,617
Human studies
7,617
Cohort signals
761
In vitro / tissue
492
Randomized trials
243
Safety adverse signals
188
Meta-analyses
79
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29551598 • 2018 Jun
Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis.
Clin Gastroenterol Hepatol
Open PubMedPMID 37554764 • 2023
Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis.
Front Endocrinol (Lausanne)
Open PubMedPMID 34617108 • 2022 Apr 8
A systematic review and meta-analysis of the benefits of a gluten-free diet and/or casein-free diet for children with autism spectrum disorder.
Nutr Rev
Open PubMedPMID 33573238 • 2021 Jan 30
The Effect of a Combined Gluten- and Casein-Free Diet on Children and Adolescents with Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 39153845 • 2024 Nov 11
Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis.
Gut
Open PubMedPMID 30046155 • 2018 Sep
A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome.
Am J Gastroenterol
Open PubMedPMID 29562612 • 2018 Mar 17
Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial.
Nutrients
Open PubMedPMID 40706614 • 2025 Sep
Effect of gluten and wheat on symptoms and behaviours in adults with irritable bowel syndrome: a single-centre, randomised, double-blind, sham-controlled crossover trial.
Lancet Gastroenterol Hepatol
Open PubMedPMID 38040019 • 2024 Feb
The effect of expectancy versus actual gluten intake on gastrointestinal and extra-intestinal symptoms in non-coeliac gluten sensitivity: a randomised, double-blind, placebo-controlled, international, multicentre study.
Lancet Gastroenterol Hepatol
Open PubMedPMID 40553742 • 2025 Dec
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
Gastroenterology
Open PubMedPMID 39861493 • 2025 Jan 20
Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimoto's Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet.
Nutrients
Open PubMedPMID 35240330 • 2022 Dec
Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet, and the Gluten-Free Diet.
Clin Gastroenterol Hepatol
Open PubMedPMID 34647492 • 2021 Dec
Gastrointestinal microbiome and gluten in celiac disease.
Ann Med
Open PubMedPMID 36321689 • 2022 Oct
Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.
Health Technol Assess
Open PubMedPMID 39940345 • 2025 Jan 29
Short- and Long-Term Nutritional Status in Children and Adolescents with Celiac Disease Following a Gluten-Free Diet: A Systematic Review.
Nutrients
Open PubMedPMID 31634384 • 2019 Aug
The impact of diet on psoriasis.
Cutis
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22gluten-containing%20grains%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=gluten-containing%20grains
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 7617, RCT 243, meta 79, cohort 761.[2975,2977,3064, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29551598 from Clin Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37554764 from Front Endocrinol (Lausanne).
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34617108 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33573238 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39153845 from Gut.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30046155 from Am J Gastroenterol.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29562612 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40706614 from Lancet Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38040019 from Lancet Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40553742 from Gastroenterology.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39861493 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35240330 from Clin Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34647492 from Ann Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36321689 from Health Technol Assess.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39940345 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31634384 from Cutis.
Outcome: See linked PubMed abstract for methods and outcomes.[2975,2977,3064, etc.]
Open source