Food
Monounsaturated fats and olive polyphenols support vascular and metabolic resilience.[2173,2818,2999, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
100
Positive Lean • confidence Low
Safety Friction
61/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 7 • links 25
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Classification: prioritize.[422,1199,2173, etc.]
Best fit: Adults with cardiometabolic risk or low intake of unsaturated fats..[422,1199,2173, etc.]
Goal alignment: Heart Health, Longevity, Metabolic Health.[422,1199,2173, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
Adults with cardiometabolic risk or low intake of unsaturated fats.
Primary Focus
Heart Health, Longevity
Clinical Depth
Humans: 540 • RCTs: 160 • Meta: 9
Cohort / Real-World
Cohort signals: 61
Safety Markers
Adverse signals: 22 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
910 total studies · 5 recent
Timeline
Total indexed
910
Human studies
540
Animal-only studies
160
Randomized trials
160
In vitro / tissue
115
Cohort signals
61
Weighted direction score: 100 (Positive Lean)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
910
Human studies
540
Animal-only studies
160
Randomized trials
160
In vitro / tissue
115
Cohort signals
61
Safety adverse signals
22
Meta-analyses
9
Distribution of evidence by study design strength
Evidence Strength: High
PMID 30864165 • 2019 Mar 13
Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease.
Cochrane Database Syst Rev
Open PubMedPMID 33941427 • 2021 Jun 30
Effect of extra virgin olive oil consumption on glycemic control: A systematic review and meta-analysis.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 40275388 • 2025 Apr 24
Effect of olive oil consumption on diabetes risk: a dose-response meta-analysis.
J Health Popul Nutr
Open PubMedBenefit reports: 2
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 5
Signal confidence: 0.39
Benefits
Adverse
No Effect
Community confidence 0.39 with mentions: benefit 1, adverse 0, no-effect 0.
Subreddit coverage: ScientificNutrition, keto, mediterraneandiet, nutrition.
post • r/mediterraneandiet • unclear
One minute you’re young and carefree, the next minute you’re telling Reddit about zucchini fritters with a herb yogurt dip. A SHARED plate of grilled shrimp, zucchini fritters with herb yogurt dip. Marinate 1 1/2 pounds extra large shrimp …
Open mentionpost • r/nutrition • unclear
will pressure cooking lentils with added creatine, extra virgin olive oil, collagen decrease their health effects? I have a tendency to forget to take my supplements and to put olive oil on my food. I'm thinking to add it to my food before…
Open mentionpost • r/ScientificNutrition • unclear
Effects of High-Phenolic Extra Virgin Olive Oil (EVOO) on the Lipid Profile of Patients with Hyperlipidemia
Evidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 540, RCT 160, meta 9, cohort 61.[2173,2818,2999, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30864165 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
Composite of study volume, RCTs, and meta-analyses
PMID 37977313 • 2024 Jan
Effect of Extra Virgin Olive Oil on Anthropometric Indices, Inflammatory and Cardiometabolic Markers: a Systematic Review and Meta-Analysis of Randomized Clinical Trials.
J Nutr
Open PubMedPMID 29708409 • 2019
The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: A systematic review and meta-analysis.
Crit Rev Food Sci Nutr
Open PubMedPMID 38889571 • 2024 Aug
Introduction of the Mediterranean diet in pregnancy and the incidence of gestational diabetes mellitus: A systematic review of randomised controlled trials and meta-analysis.
Eur J Obstet Gynecol Reprod Biol
Open PubMedPMID 28684083 • 2017 Jul
The PREDIMED trial, Mediterranean diet and health outcomes: How strong is the evidence?
Nutr Metab Cardiovasc Dis
Open PubMedPMID 23432189 • 2013 Apr 4
Primary prevention of cardiovascular disease with a Mediterranean diet.
N Engl J Med
Open PubMedPMID 34372670 • 2021 Nov
Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease: An Analysis of the CORDIOPREV Randomized Controlled Trial.
Stroke
Open PubMedPMID 37621140 • 2023 Jan-Dec
The Effect of Mediterranean Diet on Body Composition, Inflammatory Factors, and Nutritional Status in Patients with Cachexia Induced by Colorectal Cancer: A Randomized Clinical Trial.
Integr Cancer Ther
Open PubMedPMID 35030530 • 2022 Feb
Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial.
Clin Nutr
Open PubMedPMID 39045758 • 2024 Aug 6
Recipe for Heart Health: A Randomized Crossover Trial on Cardiometabolic Effects of Extra Virgin Olive Oil Within a Whole-Food Plant-Based Vegan Diet.
J Am Heart Assoc
Open PubMedPMID 38336153 • 2024 Jul
Effect of the Mediterranean diet in cardiovascular prevention.
Rev Esp Cardiol (Engl Ed)
Open PubMedPMID 31547562 • 2019 Sep 23
Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS).
Nutrients
Open PubMedPMID 31521398 • 2019 Dec
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Rev Neurol (Paris)
Open PubMedPMID 31374907 • 2019 Aug 1
Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.
Nutrients
Open PubMedpost • r/mediterraneandiet • unclear
I lowered my LDL cholesterol by 150 points in three months. Here’s how: tl;dr: * I had extremely high cholesterol levels: 354 total with LDL at 265 and HDL at 82 in November 2024. * Rather than take recommended statins, I educated myself b…
Open mentionpost • r/keto • benefit
3 months into keto and this is 100% not something I can do for the rest of my life I'm first time doing keto (ketovore) and I'm currently in at 11 weeks so almost 3 months now. My blood ketones was at the highest measurement 2.1 mmol/L. Ho…
Open mentionpost • r/mediterraneandiet • unclear
Greek Lemon Chicken This Greek Lemon Chicken recipe combines juicy, tender chicken thighs with a zesty lemon-herb marinade, delivering a burst of Mediterranean flavors. Paired with golden roasted potatoes, it’s a satisfying one-pan meal th…
Open mentionCommunity Sources
PUBMED • 2021 • Human evidence curation set
PMID 33941427 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40275388 from J Health Popul Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37977313 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 29708409 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38889571 from Eur J Obstet Gynecol Reprod Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28684083 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23432189 from N Engl J Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34372670 from Stroke.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37621140 from Integr Cancer Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35030530 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39045758 from J Am Heart Assoc.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38336153 from Rev Esp Cardiol (Engl Ed).
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31547562 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31521398 from Rev Neurol (Paris).
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31374907 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2173,2818,2999, etc.]
Open source