Food
Coffee bioactives and caffeine are linked to cognitive and cardiometabolic outcomes in many cohorts.[2242,2716,2894, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
73/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Classification: case-dependent.[1072,1187,2242, etc.]
Best fit: Users tolerating caffeine and avoiding late-day intake..[1072,1187,2242, etc.]
Goal alignment: Cognitive, Energy, Longevity.[1072,1187,2242, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users tolerating caffeine and avoiding late-day intake.
Primary Focus
Cognitive, Energy
Clinical Depth
Humans: 2,618 • RCTs: 127 • Meta: 236
Cohort / Real-World
Cohort signals: 815
Safety Markers
Adverse signals: 41 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
2618 total studies · 5 recent
Timeline
Total indexed
2,618
Human studies
2,618
Cohort signals
815
Meta-analyses
236
Randomized trials
127
In vitro / tissue
71
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
2,618
Human studies
2,618
Cohort signals
815
Meta-analyses
236
Randomized trials
127
In vitro / tissue
71
Safety adverse signals
41
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29167102 • 2017 Nov 22
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.
BMJ
Open PubMedPMID 37447390 • 2023 Jul 7
Coffee Consumption and Risk of Hypertension in Adults: Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 31055709 • 2019 Aug
Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers.
Eur J Epidemiol
Open PubMedPMID 34690004 • 2022 Jan
Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study.
Am J Kidney Dis
Open PubMedPMID 24201300 • 2014 Feb 11
Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies.
Circulation
Open PubMedPMID 33418132 • 2022 Mar
Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation.
Clin Gastroenterol Hepatol
Open PubMedPMID 41206802 • 2026 Jan 27
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial.
JAMA
Open PubMedPMID 36947466 • 2023 Mar 23
Acute Effects of Coffee Consumption on Health among Ambulatory Adults.
N Engl J Med
Open PubMedPMID 35639365 • 2023 Mar
Effect of Coffee and Tea Consumption on Adolescent Weight Control: An Interventional Pilot Study.
Child Obes
Open PubMedPMID 38308805 • 2024 Jan
Acute Effects of Coffee Consumption on Blood Pressure and Endothelial Function in Individuals with Hypertension on Antihypertensive Drug Treatment: A Randomized Crossover Trial.
High Blood Press Cardiovasc Prev
Open PubMedPMID 27858150 • 2018 Mar
Coffee and oxidative stress: a human intervention study.
Eur J Nutr
Open PubMedPMID 34564706 • 2022 Jan
CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.
Int J Obes (Lond)
Open PubMedPMID 38963648 • 2024 Dec
Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.
Geroscience
Open PubMedPMID 29474816 • 2018 May-Jun
Coffee for Cardioprotection and Longevity.
Prog Cardiovasc Dis
Open PubMedPMID 39266809 • 2025 Apr
Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.
Geroscience
Open PubMedPMID 40626862 • 2025 Sep 22
Coffee and cardiovascular disease.
Eur Heart J
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22coffee%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=coffee
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 2618, RCT 127, meta 236, cohort 815.[2242,2716,2894, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 29167102 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37447390 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31055709 from Eur J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34690004 from Am J Kidney Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24201300 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33418132 from Clin Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41206802 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36947466 from N Engl J Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35639365 from Child Obes.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38308805 from High Blood Press Cardiovasc Prev.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 27858150 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34564706 from Int J Obes (Lond).
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38963648 from Geroscience.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29474816 from Prog Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39266809 from Geroscience.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40626862 from Eur Heart J.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open source