Food
Vitamin C and flavanones support antioxidant and endothelial pathways.[2419,2575,2762, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-10
Mixed / Neutral • confidence Moderate
Safety Friction
82/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 6 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Classification: prioritize.[452,1185,2419, etc.]
Best fit: Users with low fruit intake and poor produce diversity..[452,1185,2419, etc.]
Goal alignment: Immune Support, Heart Health, Skin Hair.[452,1185,2419, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
Users with low fruit intake and poor produce diversity.
Primary Focus
Immune Support, Heart Health
Clinical Depth
Humans: 1,274 • RCTs: 168 • Meta: 28
Cohort / Real-World
Cohort signals: 182
Safety Markers
Adverse signals: 64 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
1274 total studies · 4 recent
Timeline
Total indexed
1,274
Human studies
1,274
Cohort signals
182
Randomized trials
168
In vitro / tissue
97
Safety adverse signals
64
Weighted direction score: -10 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
1,274
Human studies
1,274
Cohort signals
182
Randomized trials
168
In vitro / tissue
97
Safety adverse signals
64
Meta-analyses
28
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 28338764 • 2017 Jun 1
Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies.
Int J Epidemiol
Open PubMedPMID 32006369 • 2020
Food Color and Autism: A Meta-Analysis.
Adv Neurobiol
Open PubMedPMID 26778708 • 2016 Aug
Consumption of citrus and cruciferous vegetables with incident type 2 diabetes mellitus based on a meta-analysis of prospective study.
Prim Care Diabetes
Open PubMedPMID 33529754 • 2021 Apr
Citrus fruit intake and lung cancer risk: A meta-analysis of observational studies.
Pharmacol Res
Open PubMedPMID 33000670 • 2020 Oct 20
Relation of Different Fruit and Vegetable Sources With Incident Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.
J Am Heart Assoc
Open PubMedPMID 36658686 • 2024 Apr
Citrus fruit intake and incidence of renal cell carcinoma: A meta-analysis of observational studies.
Asia Pac J Clin Oncol
Open PubMedPMID 38732578 • 2024 Apr 28
Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial.
Nutrients
Open PubMedPMID 33808180 • 2021 Mar 30
Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus.
Nutrients
Open PubMedPMID 36615801 • 2022 Dec 28
Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial.
Nutrients
Open PubMedPMID 35276783 • 2022 Jan 18
Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study.
Nutrients
Open PubMedPMID 25588369 • 2015
Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management.
Nat Prod Res
Open PubMedPMID 39339791 • 2024 Sep 20
Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial.
Nutrients
Open PubMedPMID 31906271 • 2020 Jan 1
Fruit and Vegetable Intake and Mental Health in Adults: A Systematic Review.
Nutrients
Open PubMedPMID 39543781 • 2024 Nov 14
F. prausnitzii potentially modulates the association between citrus intake and depression.
Microbiome
Open PubMedPMID 37247693 • 2023 Aug
Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease.
Pharmacol Ther
Open PubMedPMID 36906146 • 2023 May
Kidney Stone Prevention.
Adv Nutr
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 3
Signal confidence: 0.47
Benefits
Adverse
No Effect
Community confidence 0.47 with mentions: benefit 1, adverse 1, no-effect 0.
Subreddit coverage: carnivorediet, nutrition, vegan.
post • r/vegan • adverse
The best dietary plan to get full nutrients from vegan food that I could personally find Starting, I want to point out that I'm NOT a professional, and this is just my personal research to find the least supplement-dependent diet. another …
Open mentionpost • r/vegan • unclear
Is it possible for me to be vegan with my allergies? I have always felt that it wasn’t possible for me to go vegan because of my allergies. I realize I don’t actually know for sure, I’ve just assumed. Here is my list of allergies. Are ther…
Open mentionpost • r/nutrition • benefit
I’ve listed 35 polyphenols below. In nutrition, is there a 'Goldilocks zone' for these? I'm curious if the science shows a point where taking more actually stops being helpful and becomes 'too much. 1. **Black Elderberries** 2. **Blackcurr…
Open mentionpost • r/carnivorediet • unclear
Carnivore struggles I’m not sure if this is the correct place to write this post but I’m a bit desperate. Long story short I was diagnosed with RA (rheumatoid arthritis) in 2022, alongside with osteoporosis, and now finding out that I pote…
Open mentionpost • r/carnivorediet • unclear
How do you not get Survey? Store, who spent months at sea and ate only salted pork would eventually get scurvy, which came from a lack of citrus fruits. I’m genuinely curious … if all you eat is meat, it seems like you’re missing out on so…
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 1274, RCT 168, meta 28, cohort 182.[2419,2575,2762, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28338764 from Int J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32006369 from Adv Neurobiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26778708 from Prim Care Diabetes.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33529754 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33000670 from J Am Heart Assoc.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 36658686 from Asia Pac J Clin Oncol.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38732578 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33808180 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36615801 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35276783 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25588369 from Nat Prod Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39339791 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31906271 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39543781 from Microbiome.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37247693 from Pharmacol Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36906146 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open source