Food
High-heat charring increases heterocyclic amine and PAH exposure.[1445,1613,1664, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
45/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: limit.[1067,1180,1445, etc.]
Best fit: Users frequently grilling or pan-searing to heavy char..[1067,1180,1445, etc.]
Goal alignment: Longevity, Liver Support, Metabolic Health.[1067,1180,1445, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
Users frequently grilling or pan-searing to heavy char.
Primary Focus
Longevity, Liver Support
Clinical Depth
Humans: 283 • RCTs: 5 • Meta: 7
Cohort / Real-World
Cohort signals: 55
Safety Markers
Adverse signals: 9 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
283 total studies
Timeline
Total indexed
283
Human studies
283
Cohort signals
55
In vitro / tissue
23
Safety adverse signals
9
Meta-analyses
7
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
283
Human studies
283
Cohort signals
55
In vitro / tissue
23
Safety adverse signals
9
Meta-analyses
7
Randomized trials
5
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 26689289 • 2015 Dec 21
A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer.
Nutr J
Open PubMedPMID 30275115 • 2019 Jan
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
Cancer Epidemiol Biomarkers Prev
Open PubMedPMID 29016198 • 2018 Jan
Carcinogenicity of High Consumption of Meat and Lung Cancer Risk Among Non-Smokers: A Comprehensive Meta-Analysis.
Nutr Cancer
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 283, RCT 5, meta 7, cohort 55.[1445,1613,1664, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26689289 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
PMID 28524104 • 2017 May 18
Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 17535831 • 2007 Aug 1
A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.
Am J Epidemiol
Open PubMedPMID 22011087 • 2012 May
SULT1A1 Arg213His polymorphism, smoked meat, and breast cancer risk: a case-control study and meta-analysis.
DNA Cell Biol
Open PubMedPMID 16357191 • 2005 Dec 15
A prospective study of meat and meat mutagens and prostate cancer risk.
Cancer Res
Open PubMedPMID 19223546 • 2009 Mar 1
Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.
Cancer Res
Open PubMedPMID 21541030 • 2011 Apr 25
Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt.
PLoS One
Open PubMedPMID 29873077 • 2018 Nov 1
Anatomical subsite can modify the association between meat and meat compounds and risk of colorectal adenocarcinoma: Findings from three large US cohorts.
Int J Cancer
Open PubMedPMID 19452526 • 2009 Sep 1
Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort Study.
Int J Cancer
Open PubMedPMID 24847855 • 2014 Jul
Meat, dairy, and cancer.
Am J Clin Nutr
Open PubMedPMID 34775303 • 2022 Feb
Heterocyclic amines in cooked meat products, shortcomings during evaluation, factors influencing formation, risk assessment and mitigation strategies.
Meat Sci
Open PubMedPMID 15489140 • 2004 Dec
Environmental and chemical carcinogenesis.
Semin Cancer Biol
Open PubMedPMID 22438055 • 2012 Oct 1
Meat consumption, heterocyclic amines and colorectal cancer risk: the Multiethnic Cohort Study.
Int J Cancer
Open PubMedPMID 11520423 • 2001 Aug
A critical evaluation of the application of biomarkers in epidemiological studies on diet and health.
Br J Nutr
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=charred%20meats
Community Sources
PUBMED • 2019 • Human evidence curation set
PMID 30275115 from Cancer Epidemiol Biomarkers Prev.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29016198 from Nutr Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28524104 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17535831 from Am J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22011087 from DNA Cell Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 16357191 from Cancer Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19223546 from Cancer Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21541030 from PLoS One.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29873077 from Int J Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19452526 from Int J Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24847855 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34775303 from Meat Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2004 • Human evidence curation set
PMID 15489140 from Semin Cancer Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22438055 from Int J Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11520423 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1445,1613,1664, etc.]
Open source