Food
Palatability and cooking stability can support adherence but increases saturated fat intake.[1475,1779,1990, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
27/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Classification: case-dependent.[1063,1174,1475, etc.]
Best fit: Users prioritizing taste/adherence with otherwise high-quality diet patterns..[1063,1174,1475, etc.]
Goal alignment: Body Composition, Heart Health.[1063,1174,1475, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users prioritizing taste/adherence with otherwise high-quality diet patterns.
Primary Focus
Body Composition, Heart Health
Clinical Depth
Humans: 149 • RCTs: 11 • Meta: 4
Cohort / Real-World
Cohort signals: 28
Safety Markers
Adverse signals: 3 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
149 total studies · 2 recent
Timeline
Total indexed
149
Human studies
149
Cohort signals
28
Randomized trials
11
In vitro / tissue
6
Meta-analyses
4
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
149
Human studies
149
Cohort signals
28
Randomized trials
11
In vitro / tissue
6
Meta-analyses
4
Safety adverse signals
3
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 33471083 • 2021 Apr 6
Nut consumption and type 2 diabetes risk: a systematic review and meta-analysis of observational studies.
Am J Clin Nutr
Open PubMedPMID 27355649 • 2016
Is Butter Back? A Systematic Review and Meta-Analysis of Butter Consumption and Risk of Cardiovascular Disease, Diabetes, and Total Mortality.
PLoS One
Open PubMedPMID 33307550 • 2021 Jun 1
Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption with Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies.
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22butter%20and%20ghee%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 149, RCT 11, meta 4, cohort 28.[1475,1779,1990, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33471083 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
Adv Nutr
PMID 26011901 • 2015 May
Effect of cheese consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials.
Nutr Rev
Open PubMedPMID 34656952 • 2021 Nov
Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial.
Clin Nutr
Open PubMedPMID 41632974 • 2026 Feb
Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.
J Cachexia Sarcopenia Muscle
Open PubMedPMID 34794522 • 2022 Nov 14
Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: a two-period, crossover, randomised trial.
Br J Nutr
Open PubMedPMID 20648041 • 2010 Oct
Effects of margarines and butter consumption on lipid profiles, inflammation markers and lipid transfer to HDL particles in free-living subjects with the metabolic syndrome.
Eur J Clin Nutr
Open PubMedPMID 38501177 • 2024 Jun 28
The effects of replacing ghee with rapeseed oil on liver steatosis and enzymes, lipid profile, insulin resistance and anthropometric measurements in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial.
Br J Nutr
Open PubMedPMID 17707980 • 2006 Feb
Effects of margarine and butter consumption on distribution of trans-18:1 fatty acid isomers and conjugated linoleic acid in major serum lipid classes in lactating women.
Lipids
Open PubMedPMID 28768652 • 2017 Sep
Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes.
Am J Clin Nutr
Open PubMedPMID 32727726 • 2020 Oct
Nut and Peanut Butter Consumption and the Risk of Total Cancer: A Prospective Cohort Study.
Cancer Epidemiol Biomarkers Prev
Open PubMedPMID 30642454 • 2019 Feb
Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study.
Lung Cancer
Open PubMedPMID 11978580 • 2002 May 1
Prospective study of diet and pancreatic cancer in male smokers.
Am J Epidemiol
Open PubMedPMID 35044629 • 2022 Jan
Dairy Foods: Is Its Cardiovascular Risk Profile Changing?
Curr Atheroscler Rep
Open PubMedPMID 37226031 • 2023 Sep
Dairy Foods: Beneficial Effects of Fermented Products on Cardiometabolic Health.
Curr Nutr Rep
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=butter%20and%20ghee
Community Sources
PUBMED • 2016 • Human evidence curation set
PMID 27355649 from PLoS One.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33307550 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26011901 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34656952 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41632974 from J Cachexia Sarcopenia Muscle.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34794522 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20648041 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38501177 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 17707980 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28768652 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32727726 from Cancer Epidemiol Biomarkers Prev.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30642454 from Lung Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 11978580 from Am J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35044629 from Curr Atheroscler Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37226031 from Curr Nutr Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1475,1779,1990, etc.]
Open source