Food
Endocrine-active food-contact chemicals are linked to metabolic and hormonal concern signals.[2177,2676,2701, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
97/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
66/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: limit.[1052,1156,2177, etc.]
Best fit: Users minimizing endocrine disruptor exposure burden..[1052,1156,2177, etc.]
Goal alignment: Hormone Health, Metabolic Health.[1052,1156,2177, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
Users minimizing endocrine disruptor exposure burden.
Primary Focus
Hormone Health, Metabolic Health
Clinical Depth
Humans: 217 • RCTs: 3 • Meta: 1
Cohort / Real-World
Cohort signals: 28
Safety Markers
Adverse signals: 29 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
217 total studies · 5 recent
Timeline
Total indexed
217
Human studies
217
Safety adverse signals
29
Cohort signals
28
In vitro / tissue
20
Randomized trials
3
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
217
Human studies
217
Safety adverse signals
29
Cohort signals
28
In vitro / tissue
20
Randomized trials
3
Meta-analyses
1
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33617867 • 2021 Jun
Temporal exposure and consistency of endocrine disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose.
Environ Res
Open PubMedPMID 34186503 • 2021 Jul
Web-based behavioral intervention to reduce exposure to phthalate metabolites, bisphenol A, triclosan, and parabens in mothers with young children: A randomized controlled trial.
Int J Hyg Environ Health
Open PubMedPMID 23443238 • 2013 Jul
Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures.
J Expo Sci Environ Epidemiol
Open PubMedPMID 27726525 • 2017 Feb
Randomized Intervention Trial to Decrease Bisphenol A Urine Concentrations in Women: Pilot Study.
J Womens Health (Larchmt)
Open PubMedPMID 40845633 • 2025 Sep 15
Xenobiotic-induced liver injury: Molecular mechanisms and disease progression.
Ecotoxicol Environ Saf
Open PubMedPMID 30013446 • 2018
A Review on the Effects of Bisphenol A and Its Derivatives on Skeletal Health.
Int J Med Sci
Open PubMedPMID 27498136 • 2016 Sep 15
Effects of bisphenol A on male and couple reproductive health: a review.
Fertil Steril
Open PubMedPMID 37803563 • 2023 Nov
Methodological approaches for the assessment of bisphenol A exposure.
Food Res Int
Open PubMedPMID 39315735 • 2024 Sep
Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK - Breast Cancer Prevention Conference.
Cancer Med
Open PubMedPMID 27822670 • 2017 Mar
The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders.
Endocrine
Open PubMedPMID 36190593 • 2022 Nov
A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).
J Assist Reprod Genet
Open PubMedPMID 39203868 • 2024 Aug 16
Evaluating Phthalates and Bisphenol in Foods: Risks for Precocious Puberty and Early-Onset Obesity.
Nutrients
Open PubMedPMID 34207527 • 2021 Jun 9
Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis.
Cells
Open PubMedPMID 34355365 • 2021 Aug
The effect of endocrine disruptors on the reproductive system - current knowledge.
Eur Rev Med Pharmacol Sci
Open PubMedPMID 38203845 • 2024 Jan 4
The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.
Int J Mol Sci
Open PubMedPMID 39799675 • 2025 Apr 5
Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2.
J Hazard Mater
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22BPA%20food%20packaging%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=BPA%20food%20packaging
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 217, RCT 3, meta 1, cohort 28.[2177,2676,2701, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33617867 from Environ Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34186503 from Int J Hyg Environ Health.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23443238 from J Expo Sci Environ Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27726525 from J Womens Health (Larchmt).
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40845633 from Ecotoxicol Environ Saf.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30013446 from Int J Med Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27498136 from Fertil Steril.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37803563 from Food Res Int.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39315735 from Cancer Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27822670 from Endocrine.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36190593 from J Assist Reprod Genet.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39203868 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34207527 from Cells.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34355365 from Eur Rev Med Pharmacol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38203845 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39799675 from J Hazard Mater.
Outcome: See linked PubMed abstract for methods and outcomes.[2177,2676,2701, etc.]
Open source