Food
Synthetic antioxidant preservatives are debated for long-term safety at cumulative exposures.[1387,3619,3925, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
43/100
Early depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
31/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 7 • mentions 0 • links 16
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Classification: limit.[1059,1168,1387, etc.]
Best fit: Users reducing ultra-processed packaged foods..[1059,1168,1387, etc.]
Goal alignment: Longevity, Liver Support.[1059,1168,1387, etc.]
Classification
Limit
Evidence Tier
MEDIUM
Best Fit
Users reducing ultra-processed packaged foods.
Primary Focus
Longevity, Liver Support
Clinical Depth
Humans: 34 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 1
Safety Markers
Adverse signals: 4 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
34 total studies · 2 recent
Timeline
Total indexed
34
Human studies
34
In vitro / tissue
26
Safety adverse signals
4
Cohort signals
1
Animal-only studies
0
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Medium when human evidence exists but is limited, or when non-human evidence volume is substantial.
Total indexed
34
Human studies
34
In vitro / tissue
26
Safety adverse signals
4
Cohort signals
1
Animal-only studies
0
Randomized trials
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 10942321 • 2000 Jul
Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study.
Food Chem Toxicol
Open PubMedPMID 37127924 • 2023 Oct
A review of the occurrence, metabolites and health risks of butylated hydroxyanisole (BHA).
J Sci Food Agric
Open PubMedPMID 33556417 • 2021 Apr
Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?
Regul Toxicol Pharmacol
Open PubMedPMID 40827001 • 2025 Sep
Common Food Additives Inhibit Carbonic Anhydrase Activity.
J Biochem Mol Toxicol
Open PubMedPMID 32397407 • 2020 May 9
Computational Methods for the Identification of Molecular Targets of Toxic Food Additives. Butylated Hydroxytoluene as a Case Study.
Molecules
Open PubMedPMID 39621224 • 2025 Mar
A Comprehensive Review on Preparation of Silver Nanoparticles from a Bacteriocin for the Natural Preservation of Food Products.
Appl Biochem Biotechnol
Open PubMedPMID 35588985 • 2022 Jul
Occurrence of synthetic phenolic antioxidants in foodstuffs from ten provinces in China and its implications for human dietary exposure.
Food Chem Toxicol
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 34, RCT 0, meta 0, cohort 1.[1387,3619,3925, etc.]
Open sourcePUBMED • 2000 • Human evidence curation set
PMID 10942321 from Food Chem Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37127924 from J Sci Food Agric.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33556417 from Regul Toxicol Pharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40827001 from J Biochem Mol Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32397407 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39621224 from Appl Biochem Biotechnol.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35588985 from Food Chem Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[1387,3619,3925, etc.]
Open source