Diet Protocol
Plant-sterol, viscous-fiber, soy-protein, and nut-focused strategy for LDL reduction.[3022,3785,3875, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
14/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Best fit: Users prioritizing LDL/ApoB reduction through structured nutrition..[1115,1259,3022, etc.]
Goal alignment: Heart Health, Metabolic Health.[1115,1259,3022, etc.]
Protocol Type
Diet Plan
Evidence Tier
HIGH
Best Fit
Users prioritizing LDL/ApoB reduction through structured nutrition.
Primary Focus
Heart Health, Metabolic Health
Clinical Depth
Humans: 63 • RCTs: 12 • Meta: 12
Cohort / Real-World
Cohort signals: 18
Safety Markers
Adverse signals: 1 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
63 total studies · 6 recent
Timeline
Total indexed
63
Human studies
63
Adherence/dropout signals
25
Cohort signals
18
Randomized trials
12
Meta-analyses
12
Weighted direction score: 0 (Mixed / Neutral)
High when large human trial/meta/cohort volume exists for the named dietary protocol.
Total indexed
63
Human studies
63
Adherence/dropout signals
25
Cohort signals
18
Randomized trials
12
Meta-analyses
12
Mechanistic signals
1
Safety adverse signals
1
Distribution of evidence by study design strength
Evidence Strength: High
PMID 34348965 • 2021 Aug 4
Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials.
BMJ
Open PubMedPMID 29807048 • 2018 May-Jun
Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials.
Prog Cardiovasc Dis
Open PubMedPMID 33509399 • 2021 Feb 2
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Human diet protocol literature
Counts from structured PubMed protocol-specific query set.
Outcome: Humans 63, RCT 12, meta 12, cohort 18.[3022,3785,3875, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34348965 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[,, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
J Am Coll Cardiol
PMID 39433088 • 2025 Jan
Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Adv Nutr
Open PubMedPMID 35889803 • 2022 Jul 12
Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials.
Nutrients
Open PubMedPMID 39169353 • 2024 Aug 22
A systematic review and meta-analysis of randomized trials of substituting soymilk for cow's milk and intermediate cardiometabolic outcomes: understanding the impact of dairy alternatives in the transition to plant-based diets on cardiometabolic health.
BMC Med
Open PubMedPMID 39275135 • 2024 Aug 23
The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials.
Nutrients
Open PubMedPMID 33396551 • 2020 Dec 31
Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications.
Nutrients
Open PubMedPMID 40263496 • 2025 Sep
Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials.
Eur J Clin Nutr
Open PubMedPMID 33032837 • 2021 Mar
Randomized parallel-group pilot trial (Best foods for your heart) comparing the effects of a Mediterranean Portfolio diet with a low saturated fat diet on HIV dyslipidemia.
Clin Nutr
Open PubMedPMID 34445009 • 2021 Aug 19
Development of a Portfolio Diet Score and Its Concurrent and Predictive Validity Assessed by a Food Frequency Questionnaire.
Nutrients
Open PubMedPMID 34587253 • 2021 Dec 3
Proposed Anti-Inflammatory Diet Reduces Inflammation in Compliant, Weight-Stable Patients with Rheumatoid Arthritis in a Randomized Controlled Crossover Trial.
J Nutr
Open PubMedPMID 36162007 • 2023 Jan 1
The Portfolio Diet and Incident Type 2 Diabetes: Findings From the Women's Health Initiative Prospective Cohort Study.
Diabetes Care
Open PubMedPMID 37877288 • 2023 Nov 28
Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies.
Circulation
Open PubMedPMID 38588684 • 2024 May
Associations of the glycaemic index and the glycaemic load with risk of type 2 diabetes in 127 594 people from 20 countries (PURE): a prospective cohort study.
Lancet Diabetes Endocrinol
Open PubMedPMID 40394599 • 2025 May 21
The portfolio dietary pattern and risk of cardiovascular disease mortality during 1988-2019 in US adults: a prospective cohort study.
BMC Med
Open PubMedCommunity Sources
PUBMED • 2018 • Human evidence curation set
PMID 29807048 from Prog Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33509399 from J Am Coll Cardiol.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39433088 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35889803 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39169353 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39275135 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33396551 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40263496 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33032837 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34445009 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34587253 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36162007 from Diabetes Care.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37877288 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38588684 from Lancet Diabetes Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40394599 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3022,3785,3875, etc.]
Open source