Diet Protocol
Plant-forward pattern that includes seafood while limiting other meats.[1817,1829,1860, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
24
Positive Lean • confidence Moderate
Safety Friction
14/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 9 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Best fit: Users wanting Mediterranean-like flexibility with marine omega-3 intake..[449,1254,1817, etc.]
Goal alignment: Heart Health, Longevity, Metabolic Health.[449,1254,1817, etc.]
Protocol Type
Diet Plan
Evidence Tier
HIGH
Best Fit
Users wanting Mediterranean-like flexibility with marine omega-3 intake.
Primary Focus
Heart Health, Longevity
Clinical Depth
Humans: 78 • RCTs: 6 • Meta: 3
Cohort / Real-World
Cohort signals: 6
Safety Markers
Adverse signals: 1 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
78 total studies · 1 recent
Timeline
Total indexed
78
Human studies
78
Randomized trials
6
Cohort signals
6
Adherence/dropout signals
6
Meta-analyses
3
Weighted direction score: 24 (Positive Lean)
High when large human trial/meta/cohort volume exists for the named dietary protocol.
Total indexed
78
Human studies
78
Randomized trials
6
Cohort signals
6
Adherence/dropout signals
6
Meta-analyses
3
Mechanistic signals
3
Safety adverse signals
1
Distribution of evidence by study design strength
Evidence Strength: High
PMID 35655214 • 2022 Feb 24
Association of meat, vegetarian, pescatarian and fish-poultry diets with risk of 19 cancer sites and all cancer: findings from the UK Biobank prospective cohort study and meta-analysis.
BMC Med
Open PubMedPMID 36102832 • 2023 Mar 10
Linkage between a plant-based diet and age-related eye diseases: a systematic review and meta-analysis.
Nutr Rev
Open PubMedPMID 34836356 • 2021 Nov 16
Effects of Plant-Based Diets on Weight Status in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Benefit reports: 4
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 2
Signal confidence: 0.57
Benefits
Adverse
No Effect
Community confidence 0.57 with mentions: benefit 2, adverse 1, no-effect 0.
Subreddit coverage: Biohackers, MealPrepSunday, loseit, vegan.
post • r/vegan • unclear
Rant: Flexitarians & this idea of vegans as "Too strict" I know someone who insists that she's "vegan, just flexible". She prefers vegan food, cooks vegan food, but will eat seafood and dairy if there's "no other choice". For me, if there'…
Open mentionpost • r/MealPrepSunday • unclear
Pescatarian adult lunchables? I used to love doing lunchables, and my favorite part was the smoked meats, but I'm currently transitioning to a more vegetarian/ slightly pescatarian diet. Looking for ideas to replace the meats!
Open mentionpost • r/Biohackers • mixed
Advice for doing a modified OMAD/Intermittent fast for Lent, while also running 4x per week and lifting 2x per week? How would you structure your meals and training for maximum benefit? Catholic 32M/5’11”/205lbs. Title is it but for contex…
Evidence Sources
PUBMED • Human diet protocol literature
Counts from structured PubMed protocol-specific query set.
Outcome: Humans 78, RCT 6, meta 3, cohort 6.[1817,1829,1860, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35655214 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
Composite of study volume, RCTs, and meta-analyses
Nutrients
PMID 35973188 • 2022 Oct 1
A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease.
Am J Gastroenterol
Open PubMedPMID 24850465 • 2014 Jul
A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial.
Metabolism
Open PubMedPMID 2239758 • 1990 Nov
A mixed Australian fish diet and fish-oil supplementation: impact on the plasma lipid profile of healthy men.
Am J Clin Nutr
Open PubMedPMID 1811337 • 1991 Oct 15
Fish and fish oil intake: effect on haematological variables related to cardiovascular disease.
Thromb Res
Open PubMedPMID 18759956 • 2008 Dec
Specific insulin sensitivity and leptin responses to a nutritional treatment of obesity via a combination of energy restriction and fatty fish intake.
J Hum Nutr Diet
Open PubMedPMID 1836062 • 1991 Oct
Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 40336074 • 2025 May 7
Risk of hypothyroidism in meat-eaters, fish-eaters, and vegetarians: a population-based prospective study.
BMC Med
Open PubMedPMID 35197066 • 2022 Feb 24
Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants.
BMC Med
Open PubMedPMID 35948956 • 2022 Aug 11
Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women's Cohort Study.
BMC Med
Open PubMedPMID 32717247 • 2020 Oct
Organic Diet and Intermittent Fasting are Associated With Improved Erectile Function.
Urology
Open PubMedPMID 22034926 • 2012 Jul
Incidence of amyotrophic lateral sclerosis in the Faroe Islands.
Acta Neurol Scand
Open PubMedPMID 36811593 • 2023 Jan
Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review.
Adv Nutr
Open PubMedPMID 32418548 • 2020 Oct 28
Vegetarian, pescatarian and flexitarian diets: sociodemographic determinants and association with cardiovascular risk factors in a Swiss urban population.
Br J Nutr
Open PubMedpost • r/loseit • benefit
Why does my weight loss keep stalling? I can’t get past 189lbs no matter what I do. I’m 5’8 and eating 1,900 calories a day (I also breastfeed 4-5x a day). I workout multiple times a week. I run 3x a week doing the C25K program. I go on 2 …
Open mentionpost • r/Biohackers • adverse
Biohacking B12: A Practical Flow for Detecting & Optimizing Vitamin B12 Status in Adults Vitamin B12 Deficiency: Common Questions and Answers | PMID: [40961307](https://pubmed.ncbi.nlm.nih.gov/40961307) Abstract Vitamin B12 deficiency occu…
Open mentionpost • r/loseit • benefit
Struggling with what to eat Hello, I’m really struggling with what to eat which will contain the protein that I need to feel full. I’m pescatarian so meat is off the table. I started losing weight September 2023 and was 282lbs. I am now 21…
Open mentionCommunity Sources
PUBMED • 2023 • Human evidence curation set
PMID 36102832 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34836356 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35973188 from Am J Gastroenterol.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24850465 from Metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 1990 • Human evidence curation set
PMID 2239758 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 1991 • Human evidence curation set
PMID 1811337 from Thromb Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18759956 from J Hum Nutr Diet.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 1991 • Human evidence curation set
PMID 1836062 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40336074 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35197066 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35948956 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32717247 from Urology.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22034926 from Acta Neurol Scand.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36811593 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32418548 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1817,1829,1860, etc.]
Open source