Diet Protocol
Reduced refined carbohydrate load with emphasis on protein, fiber, and minimally processed fats.[2944,2947,3512, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
100
Positive Lean • confidence Moderate
Safety Friction
93/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 8 • links 25
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Best fit: Insulin resistance and appetite-control goals..[52,1237,2944, etc.]
Goal alignment: Metabolic Health, Body Composition, Energy.[52,1237,2944, etc.]
Protocol Type
Diet Plan
Evidence Tier
HIGH
Best Fit
Insulin resistance and appetite-control goals.
Primary Focus
Metabolic Health, Body Composition
Clinical Depth
Humans: 1,242 • RCTs: 262 • Meta: 52
Cohort / Real-World
Cohort signals: 155
Safety Markers
Adverse signals: 113 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1242 total studies · 1 recent
Timeline
Total indexed
1,242
Human studies
1,242
Randomized trials
262
Cohort signals
155
Adherence/dropout signals
123
Safety adverse signals
113
Weighted direction score: 100 (Positive Lean)
High when large human trial/meta/cohort volume exists for the named dietary protocol.
Total indexed
1,242
Human studies
1,242
Randomized trials
262
Cohort signals
155
Adherence/dropout signals
123
Safety adverse signals
113
Meta-analyses
52
Mechanistic signals
49
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33441384 • 2021 Jan 13
Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data.
BMJ
Open PubMedPMID 36012064 • 2022 Aug 22
Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails.
Int J Environ Res Public Health
Open PubMedPMID 35254136 • 2022 Dec
Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis.
Nutr Health
Open PubMedPMID 38006799 • 2023 Dec
The effects of the ketogenic diet for the management of type 2 diabetes mellitus: A systematic review and meta-analysis of recent studies.
Diabetes Metab Syndr
Open PubMedPMID 33317019 • 2020 Dec 9
The Effect of Low-Fat and Low-Carbohydrate Diets on Weight Loss and Lipid Levels: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 36584702 • 2023 Mar 15
Effect of low-carbohydrate diet on depression and anxiety: A systematic review and meta-analysis of controlled trials.
J Affect Disord
Open PubMedPMID 29466592 • 2018 Feb 20
Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.
JAMA
Open PubMedPMID 37217318 • 2023 May-Jun
Comparing Very Low-Carbohydrate vs DASH Diets for Overweight or Obese Adults With Hypertension and Prediabetes or Type 2 Diabetes: A Randomized Trial.
Ann Fam Med
Open PubMedPMID 36220069 • 2022 Oct 18
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial.
Cell Rep Med
Open PubMedPMID 35276780 • 2022 Jan 18
The Impact of a High-Carbohydrate/Low Fat vs. Low-Carbohydrate Diet on Performance and Body Composition in Physically Active Adults: A Cross-Over Controlled Trial.
Nutrients
Open PubMedPMID 38627016 • 2024 Jun
Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial.
Obesity (Silver Spring)
Open PubMedPMID 34582545 • 2022 Jan 11
Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia-a randomized controlled feeding trial.
Am J Clin Nutr
Open PubMedPMID 35938780 • 2022 Oct 1
Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet.
Curr Opin Endocrinol Diabetes Obes
Open PubMedPMID 31961383 • 2020 Apr 1
Association of Low-Carbohydrate and Low-Fat Diets With Mortality Among US Adults.
JAMA Intern Med
Open PubMedPMID 36539697 • 2022 Dec 20
Association of low-carbohydrate-diet score and cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES).
BMC Geriatr
Open PubMedPMID 29456073 • 2018 Mar 6
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Cell Metab
Open PubMedBenefit reports: 3
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 5
Signal confidence: 0.52
Benefits
Adverse
No Effect
Community confidence 0.52 with mentions: benefit 3, adverse 0, no-effect 0.
Subreddit coverage: Biohackers, carnivorediet, keto, loseit, nutrition.
post • r/Biohackers • unclear
Only a low-fat diet led to a significant loss of body fat vs. a low-carb diet “When on the low-fat diet, the participants ate 550 to 700 fewer calories per day than when on the low-carb diet. Despite the large differences in calorie intake…
Open mentionpost • r/keto • unclear
Get constipated when I maintain a low carb diet I get constipated when I maintain a low carb diet. Once i eat carbs, I'm able to pass stool again. Following this advice doesn't help: \- stay hydrated : 6 glasses water a day \- boost fiber …
Open mentionpost • r/nutrition • benefit
How exactly do you get calories with low carb diet restrictions? I need about 2.5k calories a day maintenance... I should ideally stay under 20g carbs due to family history 1 lb of beef/salmon nets about 800 calories ( my typical meat/seaf…
Open mentionpost • r/carnivorediet • unclear
Shawn Baker MD on Instagram: "NEW META ANALYSIS STUDY SHOWS LOW CARB DIET KICK BUTT REGARDLESS OF CALORIES! https://www.clinicalnutritionjournal.com/article/S0261-5614%2825%2900253-5/fulltext" Thoughts on this?
Open mentionpost • r/carnivorediet • unclear
Anyone else get weird eye twitching and head pressure on high-protein / low-carb diet? Hey folks, Every time I go on a high-protein, low-carb diet, my left eye starts twitching like crazy and I get this strange “blocked” or tight feeling i…
Open mentionpost • r/loseit • benefit
Does a low carb diet let you eat tons of calories without gaining weight? Hello! So I have a bit of a random question. My mom is a caretaker for a young woman (30 years old) with developmental delays and who, due to some of her health issu…
Open mentioncomment • r/Biohackers • benefit
Important to note: the low carb diet was plant based without meat. This part is also relevant: The researchers note that the study was not designed to make diet recommendations for weight loss. Results may have been different if the partic…
Open mentioncomment • r/Biohackers • unclear
The article says the diet was "an animal-based, low-carb diet that was high in fat."?
Open mentionEvidence Sources
Community Sources
PUBMED • Human diet protocol literature
Counts from structured PubMed protocol-specific query set.
Outcome: Humans 1242, RCT 262, meta 52, cohort 155.[2944,2947,3512, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33441384 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36012064 from Int J Environ Res Public Health.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35254136 from Nutr Health.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38006799 from Diabetes Metab Syndr.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33317019 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36584702 from J Affect Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29466592 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37217318 from Ann Fam Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36220069 from Cell Rep Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35276780 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38627016 from Obesity (Silver Spring).
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34582545 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35938780 from Curr Opin Endocrinol Diabetes Obes.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31961383 from JAMA Intern Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36539697 from BMC Geriatr.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29456073 from Cell Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2944,2947,3512, etc.]
Open source