Diet Protocol
Time-restricted pattern with earlier feeding window aligned to circadian biology.[3011,3316,3353, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
65/100
Moderate depth from human/RCT/meta counts
Community Direction
100
Positive Lean • confidence Moderate
Safety Friction
14/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 8 • links 18
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Best fit: Users with glucose-control or sleep-timing goals..[184,1297,3011, etc.]
Goal alignment: Metabolic Health, Sleep, Energy.[184,1297,3011, etc.]
Protocol Type
Diet Plan
Evidence Tier
MEDIUM
Best Fit
Users with glucose-control or sleep-timing goals.
Primary Focus
Metabolic Health, Sleep
Clinical Depth
Humans: 14 • RCTs: 3 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 1 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
14 total studies
Timeline
Total indexed
14
Human studies
14
Randomized trials
3
Adherence/dropout signals
2
Meta-analyses
1
Safety adverse signals
1
Weighted direction score: 100 (Positive Lean)
Medium when human studies exist but with smaller scale, shorter duration, or weaker replication depth.
Total indexed
14
Human studies
14
Randomized trials
3
Adherence/dropout signals
2
Meta-analyses
1
Safety adverse signals
1
Cohort signals
0
Mechanistic signals
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 33139084 • 2021 Apr
Effect of early time-restricted feeding on the metabolic profile of adults with excess weight: A systematic review with meta-analysis.
Clin Nutr
Open PubMedPMID 31151228 • 2019 May 30
Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans.
Nutrients
Open PubMedPMID 34371933 • 2021 Jul 15
Eating Dinner Early Improves 24-h Blood Glucose Levels and Boosts Lipid Metabolism after Breakfast the Next Day: A Randomized Cross-Over Trial.
Benefit reports: 4
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 4
Signal confidence: 0.42
Benefits
Adverse
No Effect
Community confidence 0.42 with mentions: benefit 4, adverse 0, no-effect 0.
Subreddit coverage: ScientificNutrition.
post • r/ScientificNutrition • unclear
Disentangling the Distinct Effects of Calorie Restriction versus Time-Restricted Eating on Longevity Pathways: Calorie Deficit or Fasting Window?
Open mentionpost • r/ScientificNutrition • unclear
Association of time-restricted eating versus a whole-food plant-based diet with metabolic syndrome biomarkers: Results from NHANES 2013–2018
Open mentionpost • r/ScientificNutrition • benefit
Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on weight loss in adults with obesity: a randomized clinical trial **ABSTRACT** **Background:** Studies evaluating the effects of novel, alternative dietary appro…
Evidence Sources
PUBMED • Human diet protocol literature
Counts from structured PubMed protocol-specific query set.
Outcome: Humans 14, RCT 3, meta 1, cohort 0.[3011,3316,3353, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33139084 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,, etc.]
Nutrients
PMID 35716852 • 2022 Sep 1
The Fasting and Shifted Timing (FAST) of Eating Study: A pilot feasibility randomized crossover intervention assessing the acceptability of three different fasting diet approaches.
Appetite
Open PubMedPMID 29754952 • 2018 Jun 5
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
Cell Metab
Open PubMedPMID 37880791 • 2023 Oct 25
The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: study protocol for a randomized clinical trial.
Trials
Open PubMedPMID 35300752 • 2022 Mar 9
The Effect of Early Time-Restricted Feeding on Glycemic Profile in Adults: A Systematic Review of Interventional Studies.
Rev Diabet Stud
Open PubMedPMID 32729615 • 2020 Oct 1
Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.
Am J Clin Nutr
Open PubMedPMID 31339000 • 2019 Aug
Early Time-Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans.
Obesity (Silver Spring)
Open PubMedpost • r/ScientificNutrition • unclear
Effects of Time-Restricted eating on Body composition and Metabolic parameters in Overweight and Obese Women
Open mentionpost • r/ScientificNutrition • unclear
Effects of Time-Restricted Eating on Glycemic control in Type 2 Diabetes
Open mentionpost • r/ScientificNutrition • benefit
Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on weight loss in adults with obesity: a randomized clinical trial Abstract Background: Studies evaluating the effects of novel, alternative dietary approaches fo…
Open mentioncomment • r/ScientificNutrition • benefit
**Abstract** Emerging evidence from animal studies suggests fasting is required for the geroprotective effects of calorie restriction (CR), but its relevance in humans remains unclear. In this perspective, we discuss the unique impact of i…
Open mentioncomment • r/ScientificNutrition • benefit
I think time-restricted eating deserves praise as multiple trials show it helps with weight management, but the claim that there is important weight-independent benefit seems exaggerated. Majority of the human studies show larger weight lo…
Open mentionCommunity Sources
PUBMED • 2019 • Human evidence curation set
PMID 31151228 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34371933 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35716852 from Appetite.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29754952 from Cell Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37880791 from Trials.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35300752 from Rev Diabet Stud.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32729615 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31339000 from Obesity (Silver Spring).
Outcome: See linked PubMed abstract for methods and outcomes.[3011,3316,3353, etc.]
Open source